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This is an extremely potent natural psychedelic found in certain plants and the poisonous secretions of the Sonoran Desert Toad. True, also known as the Colorado River Toad. It can also be generated in a laboratory synthetically. That’s the abbreviation for 5-Methoxy-N, N-Dimethyltryptamine. This drug stands out as one of the most powerful psychedelic drugs currently available.

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Taken in the presence of a sitter with no other drugs or contraindicated medications (such as MAOI antidepressants), it appears to be relatively safe. Otherwise, the report includes chronic anxiety after just one use, along with sleep disruption and panic attacks. Starting with low, accurately monitored doses, and having an experienced sitter present to help minimize the risks, is a good idea.

The period of the impact is anywhere from 20 to 60 minutes, which is one of the interesting things about it.

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Crossroads Recovery Center of Northern Mexico, which specializes in ibogaine and 5-MeO-DMT combination therapy. It appears to work synergistically with the ibogaine by motivating patients to combine the ibogaine with a transcendental or spiritual experience. It helps patients to recontextualize their experience and, in the end, can give them inspiration and motivation.

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DMT also occurs in many plants and animals, including the venom of a particular toad. More of a change in perspective, DMT is. Some have said it’s something like a near-death impression.

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How to Use DMT

The DMT yielded by the processes outlines above leaves you with a fine, white to brownish powder. Here’s how to use freebase DMT powder:

1. Vape It

Vaporizing DMT is the simplest method of using it. There are two main ways to do this:

Make a DMT-charged E-Liquid — dissolve the powder into an E-liquid base (readily available online) and then fill an E-liquid vape pen with the DMT-charged E-juice. You can make the juice as strong as you want, but the most common ration is 1:1. This means you should add about 1 gram of DMT powder for every 1 mL of E-liquid.

Vape raw DMT powder in a mesh or mod vape pen — These devices contain a stainless steel mesh that holds the powder above the heating element. This is the best method for single-hit breakthroughs. The downside is that these devices are more expensive and take some finessing to get them to work properly.

2. Smoke It

DMT can be smoked in a pipe or bong. It’s going to be very harsh no matter how you smoke it. Some people like to use the crack-style pipes to smoke DMT because they can control the temperature of it better than having to put the flame on it directly.

Never use DMT powder without weighing it first. This stuff is exceptionally strong.

3. Eat It

If you eat DMT powder directly, nothing will happen. You need to mix it with a monoamine oxidase inhibitor first for it to work.

This is some tricky business and not something anybody should attempt without adequate knowledge and oversight from experienced users. There are two categories of MAO inhibitors to consider — herbal MAO inhibitors and pharmaceutical MAO inhibitors.

The preparation most people use for this is called pharmahuasca. The concept simulates ayahuasca using synthetic ingredients. This means mixing DMT with a prescription MAO inhibitor like Isocarboxazid (Marplan). This combination can be dangerous — Marplan is a powerful drug with a long list of potential side effects.

Herbal options include Syrian Rue and Ayahuasca vine. They can be made into a very strong tea and mixed with DMT. The experience using this method will range substantially from being not psychoactive at all to powerfully psychoactive.