LSD vs. Magic Mushrooms LSD is very comparable to magic mushrooms in terms of effects. Both LSD and the active ingredient in magic mushrooms (psilocybin) share a very similar structure and interact with the same receptors in the body.
The difference in these two compounds is subtle — mushrooms tend to have a stronger “body high” and have a shorter duration of effects (about 4 – 6 hours). LSD is more “mental”, producing striking changes in visual and auditory sensory perception.
The psychoactive dose is similar for both compounds — starting at around 20 mcg of pure LSD or pure psilocybin.